Chambered dispensing devices and methods for dispensing an amount of a preparation involve the use of a handheld dispensing system having a connecting body housing one or more preparation vials, a delivery spout, and a computer system or microprocessor controlled circuit that controls dispensing of the preparation(s), optionally in combination with a mobile application that allows an individual or user to interact with the chambered dispensing device via a mobile computing device, such as a smart phone. A mobile application can provide a graphic user interface that facilitates operation of the chambered dispensing device by the individual or user, optionally via dispensing device keypad buttons, to dispense micro-dose amounts of primary and secondary cannabinoids or other preparations or substances.