Systems and methods for real time laparoscopic navigation. Exemplary embodiments can comprise scanning a structure of interest internal to a patient to provide image data； generating a first three-dimensional reconstruction of the structure of interest based on the image data； annotating the first three-dimensional reconstruction of the structure of interest with a plurality of reference points； obtaining spatial coordinates of the plurality of reference points during a laparoscopic procedure； and generating a second three-dimensional reconstruction of the structure of interest based on the spatial coordinates.
