Aspects of the present invention are directed to compositions that are useful for delivery of an active ingredient to a subject. Some embodiments are formulated with an active ingredient including for example a non steroidal anti inflammatory drug (NSAID) such as aspirin ibuprofen ketoprofen or naproxen acetaminophen or a polypeptide or protein such as insulin wherein the active ingredient is stabilized and greater than 90% of the particles of the active ingredient have a particle size that is less than or equal to or any number in between 100 90 80 70 60 50 40 30 20 19 18 17 16 15 14 13 12 11 10 9 8 7 6 5 or 4 nanometers or smaller as determined by Dynamic Light Scattering (DLS) using a volume weighted particle size distribution calculation method.
