Kyle Douglas Allen,Jon Paul Dobson,Elena Georgina Yarmola,Zachary Kaufman,David P. Arnold
申请号：
US13967571
公开号：
US20140052020A1
申请日:
2013.08.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided herein is a magnetic apparatus for collecting superparamagnetic particles from a subject. The superparamagnetic particles are previously injected into the subject and have ligands bound thereto that are specific for one or more non-cell biomarkers. In one embodiment, the superparamagnetic particles are injected into and retrieved from a cavity such as a joint cavity. These compositions and methods allow for the sequestration and removal of inflammatory mediators, as both a diagnostic of the local immune response and a therapeutic that can reduce inflammation in the local disease environment.
