Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.本發明係揭示會抑制抗細胞凋亡Bcl-2蛋白質活性之化合物,含有該化合物之組合物,及治療在此段期間內表現抗細胞凋亡Bcl-2蛋白質之疾病之方法。