Metode za determinacijo razlik v alfa- 4 integrin aktivnosti s korelacijo razlik v SVCAM in/ali SMADCAM nivojih

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专利权人:

Biogen MA Inc.

发明人:

CHACKERIAN Alissa A.

申请号：

SI201131889

公开号：

SI3326645T1

申请日:

2011.10.24

申请国别(地区):

SI

年份:

2020

代理人:

摘要：

Provided herein is a method of monitoring the change of the alpha-4 integrin activities in an individual by correlating with the soluble vascular cell adhesion molecule (sVCAM) and/or soluble mucosal addressin cell adhesion molecule (sMAdCAM) levels. Particularly, this method can be used, for example, to evaluate the pharmacokinetics and pharmacodynamics (PK/PD) of an alpha-4 integrin inhibitor used to treat a disease associated with pathological or chronic inflammation.

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中国工程科技知识中心

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