The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.本發明係關於化合物,其抑制二肽基肽酶IV(DPP-IV)且其可用於預防或治療糖尿病、尤其II型糖尿病,以及高血糖症、代謝症候群、高胰島素血症、肥胖症、動脈粥樣硬化、各種免疫調節疾病及其他疾病。