ANTICORPS MONOCLONAL POUVANT SE LIER A UN EPITOPE DISCONTINU SPECIFIQUE APPARAISSANT DANS UNE REGION AD1 D'UNE GLYCOPROTEINE GB DE CYTOMEGALOVIRUS HUMAIN, ET FRAGMENT DE LIAISON A UN ANTIGENE DUDIT ANTICORPS
Disclosed are: a pharmaceutical composition which comprises a monoclonalantibody capable of bindingspecifi-cally to an AD1 region of gB glycoprotein of human cytomegalovirus(HCMV) (which is a virus causing various diseasecondi-tions) and having an excellent neutralizing ability for HCMV and anantigen-binding fragment of the monoclonal antibody； amonoclonal antibody which can bind specifically to a discontinuous sequenceoccurring in an AD1 region of HCMV and has anexcellent neutralizing ability for HCMV and an inhibitory ability on theintercellular infection of HCMV, and an antigen-bindingfragment of the monoclonal antibody； a pharmaceutical composition comprisingthe antibody or a fragment thereof； and others.
