Disclosed are: a therapeutic and/or prophylactic agent for migraine, which comprises a compound having an antagonistic activity selective for an adenosine A2A receptor or a pharmaceutically acceptable salt thereof as an active ingredient a therapeutic and/or prophylactic agent for migraine, which comprises a compound having an antagonistic activity selective for an adenosine A2A receptor or a pharmaceutically acceptable salt thereof as an active ingredient, wherein the compound has an affinity for an adenosine A2A receptor higher by 10 times or more than that for an adenosine A1 receptor and others.
