The present invention relates to a pesticide composition for preventing and treating fusarium head blight comprising, for per mu of farmland, 1 to 150 parts by weight of validamycin and 1 to 30 parts by weight of tebuconazole. The pesticide composition of the present invention has a significant synergetic effect on preventing and treating fusarium head blight, and can significantly improve the head blight preventing and treating effect and the fusarium head blight preventing and controlling capability of mankind; the pesticide composition significantly reduces the pollution level of DON toxin in wheat, reduces the dosage, the costs, environmental pollution and pesticide residues, and retards the drug resistance of wheat pathogenic fungus to tebuconazole to prevent and treat fusarium head blight; moreover, the pesticide composition prolongs the duration of action of validamycin, reduces the application frequency, and can also treat powdery mildew, rust disease, leaf blight, and sheath blight of Triticeae crops
