The present invention relates to a method for assessment of a state of the central nervous system (CNS) of a subject and/or differentiation between states of the central nervous system (CNS) of a subject at a specific time point based on electrophysiological recordings of signals from at least two anatomical structures, wherein the signals are recorded from recording sites located in the anatomical structures, wherein the electrophysiological recordings comprise spatiotemporal fluctuations in the recorded extracellular potential, wherein the electrophysiological recordings are action potentials and/or local field potentials (LFPs) in the anatomical structures and represent the state of the CNS at said specific timepoint. The present invention further relates to the use of the method for assessment of a state of the CNS and/or differentiation of at least two states of the CNS, as well as to the use of the method for evaluating the effect of a treatment of a condition or disease, wherein the condition or disease is neurological and/or psychiatric. The invention also relates to a system for assessment of a state of the central nervous system (CNS) of a subject and/or differentiation between states of the central nervous system (CNS) and to the use of such system for assessment of a state of the CNS and/or differentiation of at least two states of the CNS, as well as to the use of such systems for evaluating the effect of a treatment of a condition or disease, wherein the condition or disease is neurological and/or psychiatric.La présente invention concerne un procédé pour l'évaluation d'un état du système nerveux central (SNC) d'un sujet et/ou la différenciation entre des états du système nerveux central (SNC) d'un sujet à un point temporel spécifique, sur la base d'enregistrements électrophysiologiques de signaux provenant d'au moins deux structures anatomiques, les signaux étant enregistrés à partir de sites d'enregistrement situés dans les structures anatomiques, le
