AN IMPROVED PROCESS FOR THE PREPARATION OF RIVAROXABAN

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专利权人:

发明人:

JAYARAMAN VENKATRAMAN,TOMER SANJIV,KANZARIYA KAMLESH,PATEL NILAV,DOLIA MITUL

申请号：

IN2219/MUM/2012

公开号：

IN2012MU02219A

申请日:

2012.08.01

申请国别(地区):

IN

年份:

2014

代理人:

摘要：

The present invention relates to a process for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3- oxazolidin-5-yl}methyl)-2-thiophen-carboxamide (I) by reacting 5-chlorothiphene-2-carbonyl chloride and 4-[4-((S)-4-aminomethyl- 2-oxoimidazolidin-l-yl)phenyl]morpholine-3-one hydrochloride in the presence of buffer reagent.

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