The present invention encompasses FMDV vaccines or compositions, wherein the vaccine or composition may be a vaccine or composition containing FMDV antigens, and wherein the FMDV antigens are FMDV-E2 fusion proteins. The invention also encompasses the corresponding recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV. The invention further encompasses methods of making or producing the corresponding antigenic polypeptides or antigens.
