ACTIVATING MITOTIC CHECKPOINT CONTROL MECHANISMS

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专利权人:

The Regents of the University of Michigan

发明人:

Ajit P. Joglekar,Pavithra Aravamudhan

申请号：

US16836335

公开号：

US20200231639A1

申请日:

2020.03.31

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided herein are compositions and methods for the treatment of cancer by activating the spindle assembly checkpoint (SAC) in cells. In particular, dimerized Mps1 and Spc105/KNL1 constructs are provided as tunable activators of SAC, allowing for control of chromosome segregation accuracy and prevention of aneuploidies that are common in cancer.

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中国工程科技知识中心

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http://www.ckcest.cn/home/