ЛИ, Эун Соо (US),ДЖАЙН, Амит К. (US),СИНГХ, Парминдер (US)
申请号：
RU2019105279
公开号：
RU2019105279A
申请日:
2017.07.26
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises drug reservoir layer comprised of an acrylate copolymer, glycerine, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent that is bioequivalent to administration of the therapeutic agent orally.
