COMBINATION OF AROMATASE INHIBITORS AND PROGESTERONE ANTAGONISTS IN THE TREATMENT OF BREAST CANCER

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专利权人:

REPROS THERAPEUTICS INC.

发明人:

PODOLSKI, JOSEPH, S

申请号：

NZ58953409

公开号：

NZ589534A

申请日:

2009.04.27

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a combination comprising a 21-substituted 19-norpregnadiene of formula (I) and an aromatase inhibitor. Specific examples of aromatase inhibitors are anastrozole, letrozole, exemestane and DL-aminoglutethimide. Specific examples of compound of formula (I) include: 21-propionyloxy-17[alpha]-acetoxy-11[beta]-(4N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, and 21-vinyl ether-17[alpha]-acetoxy-11[beta]-(4N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione The combination is useful for suppressing breast cancer tissue proliferation

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