Methods of treating, preventing or ameliorating one or more symptoms of hepatitis C in a subject comprising the step of administering at least one HCV protease inhibitor in combination with food are provided. Also provided are methods of increasing bioavailability of an HCV protease inhibitor and methods of increasing serum levels of an HCV protease inhibitor in a subject. All methods comprise adminstering at least one HCV protease inhibitor in combination with food, the at least one HCV protease inhibitor selected from the group consisting of compounds of Formulae I-XXVI, described herein. Administration of compounds of the present invention in combination with food provides improved bioavailability and increased peak serum levels of the compounds as compared to administration without food.本發明係提供在病患中治療、預防或改善C型肝炎之一或多種病徵之方法，其包括投予至少一種HCV蛋白酶抑制劑且併用食物之步驟。本發明亦提供增加HCV蛋白酶抑制劑之生體可用率之方法，及在病患中增加HCV蛋白酶抑制劑之血清含量之方法。所有方法均包括投予至少一種HCV蛋白酶抑制劑且併用食物，該至少一種HCV蛋白酶抑制劑係選自包括本文中所述之式I-XXVI化合物。本發明化合物併用食物之投藥，當與未使用食物之投藥比較時，係提供經改良之生體可用率，且增加化合物之尖峰血清含量。
