Goldenberg, David M.,Chang, Chien-Hsing,Hansen, Hans J.
申请号：
AU2009274129
公开号：
AU2009274129B2
申请日:
2009.07.21
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention provides substituted humanized, chimeric or human anti-CD20 antibodies or antigen binding fragments thereof and bispecific antibodies or fusion proteins comprising the substituted antibodies or antigen binding fragments thereof. The antibodies, fusion proteins or fragments are useful for treatment of B-cell disorders, such as B-cell malignancies and autoimmune diseases, as well as GVHD, organ transplant rejection, and hemolytic anemia and cryoglobulinemia. Amino acid substitutions, particularly substitution of an aspartate residue at Kabat position 101 of CDR3 V
