Richard D. Dimarchi;Joseph Chabenne;Maria Dimarchi
发明人:
Richard D. Dimarchi,Maria Dimarchi,Joseph Chabenne
申请号：
US12522129
公开号：
US08669228B2
申请日:
2008.01.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Modified glucagon peptides are disclosed having improved solubility while retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with, and/or addition of, charged amino acids to the carboxy terminus of the peptide. The modified glucagon agonists can be further modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, or both to further enhance the solubility of the glucagon agonist analogs.
