Preparation of Enteric microcapsules by Ionic gelation of Alginate containing Diclofenac or one of its Salts and Pharmaceutical composition that contains multiparticulada
1. A procedure that can be used to produce uncoated intestinal microcapsules containing xylene or an oral salt (sodium, potassium, epolamine) with satisfactory anti-inflammatory activity and low gastric aggression； and a pharmaceutical component containing the substance. The process includes four steps: (a) preparation of water ethanol mixture containing sodium alginato in the presence of surface activity and sodium carbonate, adding xylene or one of the previously completely dissolved salts；(b) The former solution (water-soluble calcium salt) solution is slowly incorporated into the solution to produce a gel； (c) the microcapsules separated from 1 / 1000 sodium alginato aqueous solution are revived； and (d) the resulting microcapsules are separated and dried and screened through 1000 and 1000 mesh sieves； 250 mmThe part between the two mesh mesh was selected to make the selected drug components, while the other parts were excluded. The drug composition contained in the microcapsule (to determine the local adhesion) can be in the form of oral capsule, compression agent, chewing tablet or water suspension before the patient takes it. It also refers to the pharmaceutical components of intestinal microcapsules containing uncoated polymers of phenol dichloride related to proton pump inhibitors (e.g,omeprazol) industrialmente conocidos y disponibles bajo la forma de pellets ent ricos en composici n farmac utica de uso oral que contiene ambos principios activos en la misma composici n Reivindicaci n 1 Procedimiento de elaboraci n de microc psulas ent ricas de alginato de calcio de composici n polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate； polyoxyethylene sorbitan monolaurate； and sodium bicarbonate at a temperature below 60 ° C； B) incorporate the solution obtained in A) into a solution of calcium chloride controlling the temperature below 60 ° C, during the whole process； C) resuspend the microcapsules formed and isolated without prior drying
