POIRIER, Nicolas,GAUTTIER, Vanessa,MARY, Caroline,PENGAM, Sabrina,VANHOVE, Bernard
申请号：
AU2019233577
公开号：
AU2019233577A1
申请日:
2019.03.13
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The invention is in the field of immunotherapy. The present invention provides antibodies useful in therapeutic and diagnostic applications targeting human SIRPa, said antibodies enhancing the cross-presentation of antigens to T cells. The invention also provides antibodies against specific isoforms of SIRP a and able to disrupt the interaction between those isoforms of SIRP a and human CD47 for use in treating or preventing a disease, or diagnostic applications, and methods for producing and/or selecting anti-human SIRPa antibodies that bind with different affinities to various isoforms of human SIRP members.
