compound, composition, method for preparing a composition, use of a compound, and methods for treating diseases, for inhibiting an allergic dust mite peptidase, for exterminating mites, for controlling a population of mites
ST GEORGE'S HOSPITAL MEDICAL SCHOOL;THE UNIVERSITY OF MANCHESTER
发明人:
CLIVE ROBINSON
申请号：
BR112012017476
公开号：
BR112012017476A2
申请日:
2011.01.21
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
"compound, composition, method for preparing a composition, use of a compound, and methods for treating diseases, for inhibiting a mite peptidase allergen, for exterminating mites, for controlling a population of mites" The present invention relates to generally within the field of therapeutic compounds, and more specifically to certain pyruvamide compounds of formula (x) (referred to herein collectively as "pva compounds"), which, inter alia, inhibit a mite peptidase allergen. dust from group 1 (eg der p 1, der f 1, eur m 1). The present invention also relates to pharmaceutical compositions comprising said compounds, and to the use of said compounds and compositions, both in vitro and in vivo, to inhibit a group 1 mite peptidase allergen, and in the treatment of diseases and disorders. which are mediated by a group 1 dust mite peptidase allergen； which are enhanced by inhibition of a group 1 mite peptidase allergen； asthma； rhinitis； allergic conjunctivitis； atopic dermatitis； an allergic condition that is triggered by mite； an allergic condition that is triggered by a group 1 mite peptidase allergen； and canine atopy."composto, composição, método para preparar uma composição, uso de um composto, e, métodos para tratar doenças, para inibir um alérgeno peptidase do ácaro da peira, para exterminar ácaros, para controlar uma população de ácaros" a presente invenção refere-se geralmente ao campo dos compostos terapêuticos, e, mais especificamente, a determinados compostos de piruvamida da fórmula (x) (referidos aqui coletivamente, para maior facilidade, como "compostos de pva"), que, inter alia, inibem um alérgeno peptidase do ácaro da poeira do grupo 1 (p.ex., der p 1, der f 1, eur m 1). a presente invenção refere-se também a composições farmacêuticas compreendendo referidos compostos, e ao uso de referidos compostos e composições, tanto in vitro e in vivo, para inibir um alérgeno peptidase do ácaro da peira do grupo 1, e no tratamento de doenças e distúrbios que são
