The present application provides a medicament for preventing and / or treating diseases caused by activation of EP4 receptor. A compound with antagonistic activity to EP4 receptor is contained in the medicament as an active component. Compounds, salts, n ￣ oxides or solvent complexes represented by the following general formula (I), or their prodrugs, can be used as pharmaceutical components with antagonistic activity against EP4 receptors for the prevention and / or treatment of diseases caused by EP4 receptor activation. In the following formula, all symbols are as defined in the specification.本申請提供了用於預防和／或治療由EP4受體活化引起的疾病的藥劑。在所述藥劑中含有對EP4受體具有拮抗活性的化合物作爲活性成分。由以下通式(I)表示的化合物、其鹽、N‑氧化物或溶劑合物，或這些的前藥可用作對EP4受體具有拮抗活性的藥物成分，用於預防和／或治療由EP4受體活化引起的疾病。在下式中，所有符號均如說明書中所定義。
