FORME CRISTALLINE D'HYDRATE DE BASE LIBRE DE LORLATINIB

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专利权人:

PFIZER INC.

发明人:

BOWLES, PAUL,ROSE, PETER ROBERT

申请号：

CA3077508

公开号：

CA3077508A1

申请日:

2018.10.04

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

This invention relates to a crystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclo- tetradecine-3-carbonitrile (lorlatinib) free base hydrate (Form 24). This invention also relates to pharmaceutical compositions comprising Form 24, and to methods of using Form 24 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.

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