BRUS Lars (SE),БРУС Ларс (SE),LJuNSTADUS Stole Peter (NO),ЛЮНСТАДУС Столе Петер (NO),BRUS LARS,LJUNSTADUS STOLE PETER
申请号：
RU2009113579/15
公开号：
RU0002446809C2
申请日:
2007.09.11
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to the use of a metal of group 4 or 5 of the periodic system specified in titanium, zirconium, hafnium, niobium and tantalum, or its oxide for preparing a drug used for treating or preventing a disease characterised by undesired expression and/or release of interferon-γ inducible protein of weight 10 kDa, IP-10 in a subject. The invention also refers to a method of treating or preventing the disease characterised by undesired expression and/or release of interferon-γ inducible protein of weight 10 kDa, IP-10, which implies the extraction of a biological fluid in a subject suffering said disease, the ex vivo contact of the biological fluid and the metal specified in titanium, zirconium, hafnium, niobium and tantalum, or its oxide, the fluid return after the contact with the metal to the subject stated above. The invention also provides the use of the method stated above or its oxide for the in vitro removal of interferon-γ inducible protein of weight 10 kDa, and a method for removing said protein. The invention also refers to a device for biological fluid purification which comprises a purification chamber with a fluid inlet and outlet and containing metal particles specified in titanium, zirconium, hafnium, niobium and tantalum, or its oxide, used for biological fluid purification, and a filter coupled with the fluid inlet and outlet to prevent said particles from escaping from the purification chamber.EFFECT: invention provides the selective decrease of expression and release of chemokine, namely interferon-γ inducible protein of weight 10 kDa, IP-10.25 cl, 6 tbl, 16 dwgИзобретение относится к применению металла 4 или 5 группы периодической системы элементов, выбранного из титана, циркония, гафния, ниобия и тантала или его оксида, для изготовления лекарственного средства для лечения или предотвращения заболевания, характеризующегося нежелательной экспрессией и/или высвобождением индуцируемого интерфероном
