It is discovered that the combination of eprosartan and amlodipine resulted in a synergistic treatment of hypertension or a symptom associated therewith in a subject. Improved methods and compositions for treating hypertension or a symptom associated therewith in a subject based on the combination are described.經發現依普羅沙坦與氨氯地平的組合得致個體中高血壓或其相關症狀之協同治療。本案說明基於該組合用來治療個體中高血壓或其相關症狀的改良方法與組合物。