32/3abde4a4b299 20a20b13The present invention provides a novel compound having P2X and/or P2X receptor antagonism. A compound indicated by formula (I) or a pharmaceutically acceptable salt thereof. In formula (I) R and R together and R and R together form an oxo or the like R and R are hydrogen or the like n is 1 or the like R is an aryl or the like s and s are 0 or the like R and R are a halogen or the like R and R are hydrogen an alkyl or the like u is 1 4 and R is hydrogen or the like.