VERFAHREN ZUR VERWENDUNG VON (4S,4AS,5AR,12AS-)-4-DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(METHYL)AMINO)-METHYL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACEN-2-CARBONSÄUREAMID
WARNER CHILCOTT COMPANY, LLC;PARATEK PHARMACEUTICALS; INC.;PARATEK PHARMACEUTICALS, INC.
发明人:
COULTER, CATHERINE,JOHNSTON, SEAN, M.,SEYEDI, FARZANEH,DEVRIES, TINA, M.
申请号：
EP13790638
公开号：
EP2849757A4
申请日:
2013.05.14
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
A method of treating a bacterial infection, e.g., a bacterial infection with methicillin resistant Staphylococcus aureus, Helicobacter pylori, Chlamydia trachomatis, or Chlamydia pneumonia, comprising administering to a subject (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide or a pharmaceutically acceptable salt thereof is disclosed. More specifically, a method of treating a bacterial infection comprising administering to a subject crystalline mono hydrochloride salt, crystalline mono mesylate salt or crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed.
