A personal care composition comprising (a) a yeast extract, (b) Hexapeptide- 11 (Phe-Val-Ala-Pro-Phe-Pro) (SEQ ID NO: 1), and (c) a determatologically-acceptable carrier, wherein the total amount of components (a) and (b) is from about 2 wt% to about 6wt%, preferably from 4-6% based on the total weight of the personal care composition. Also disclosed is a method for regulating skin conditions by using this composition.