HYND, GEORGE,TISSELLI, PATRIZIA,CLARK, DAVID EDWARD,KULAGOWSKI, JANUSZ JOZEF,MACLEOD, CALUM,MANN, SAMUEL EDWARD,ROUSSEL, FABIEN JEAN GHISLAIN,PRICE, STEPHEN COLIN,MONTANA, JOHN GARY
申请号：
CA2922633
公开号：
CA2922633A1
申请日:
2014.09.25
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-?B-inducing kinase (NIK -also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disordersand autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
