ANTIBODIES AND EPITOPES SPECIFIC TO MISFOLDED PRION PROTEIN

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专利权人:

发明人:

CASHMAN NEIL R

申请号：

IN6631/CHENP/2011

公开号：

IN2011CN06631A

申请日:

2011.09.15

申请国别(地区):

IN

年份:

2013

代理人:

摘要：

The present invention relates to antibodies and immunogenic peptides specific to misfolded prion protein (PrP e g PrPSc) and uses thereof. The immunogenic peptides comprise the amino acid sequence tyrosine-methionine-leucine (YML). The antibodies or peptides can be used for treating or preventing a disease or disorder associated with misfolded PrP including cancer. In particular a IgM monoclonal antibody designated 1A1 was generated using a peptide consisting of the sequence GGYMLGS (i e SEQ ID NO 8) which corresponds to residues 126-132 of human PrP 1A1 recognizes misfolded PrP but not normal PrP.

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中国工程科技知识中心

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http://www.ckcest.cn/home/