The invention relates to a combination of two or more pharmaceutically active substances, of which at least one is a metabolic product ("metabolite") of the other ("parent substance"), wherein in particular the dosages thereof are selected such that genotypically or phenotypically related variability in the conversion of the parent substance to the metabolite in particular individuals is compensated for.本發明係關於二或多種醫藥上活性物質之組合物，其中至少一物質(「代謝物」)為另一物質(「母體物質」)之代謝產物，其中特言之係選擇其劑型，使得特別是個體得以補償母體物質轉變為代謝物之基因型或表型上相關的變異。
