The Trustees of The University of Pennsylvania;University of Pittsburgh - Of the Commonwealth System of Higher Education;Novartis AG
发明人:
BROGDON, Jennifer,LOEW, Andreas,JOHNSON, Laura Alexandra,JUNE, Carl H.,MAUS, Marcela,SCHOLLER, John,OKADA, Hideho
申请号：
ES14713280
公开号：
ES2760023T3
申请日:
2014.02.20
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain.
