Document Name] [Abstract] A medicament characterized in that (A) a compound represented by the formula (I)； OP 0 ,A 1 0 , ., . N - A 2 -k, ,,,N `N)1PA4).A3 (I) n R 1 , its pharmaceutically acceptable salt, or a solvate thereof, wherein P is hydrogen or a group to form a prodrug； Al is CRiARIB, S or 0； A 2 is CR2AR2B, S or 0； A 3 is CR 3A R 3B , S or 0； A 4 is each independently CR4AR4B, S or 0； the number of hetero atoms among atoms constituting the ring which consists of Al, A 2 , A 3 , A 4 , nitrogen atom adjacent to Al and carbon atom adjacent to A 4 is 1 or 2； WA and R IB are each independently hydrogen, halogen, alkyl or the like； R 2A and R 2 B are each independently hydrogen, halogen, alkyl, or the like； R 3 A and R 3 B are each independently hydrogen, halogen, alkyl, or the like； R 4A are each independently hydrogen, halogen, alkyl, or the like； R 4 B are each independently hydrogen, halogen, alkyl, or the like； R 3 A and R 3B may be taken together with an adjacent carbon atom to form non- aromatic carbocycle or non-aromatic heterocycle； n is any integer of 1 to 2； and R.' is vvvw F = * . * S or the like, is combined with (B) compound(s) having an anti-influenza activity, its pharmaceutically acceptable salt or a solvate thereof and/or an antibody having anti- influenza activity, is useful for treating or preventing influenza.
