A system for the controlled administration of a substance by means of an infusion device implanted in the human body is described. The system has an implantable unit for detecting a shortage or an excess of such substance or a physiological parameter correlatable to the shortage or excess of such substance, an infusion group of this substance implantable in the peritoneal cavity and having a central control unit for processing data received from the detection unit, and energy storage means to power such infusion group. The system also has a carrier of such substance adapted to be ingested, and a refilling device for refilling the infusion group with such substance.
