The present invention relates to a drug delivery device for expelling a dose of drug from a held cartridge and that defines a distal drug outlet end and an opposite proximal end. The drug delivery device comprises: a distal housing component (110) holding a cartridge (113) comprising a liquid drug and a piston slideable arranged therein in an axial direction, and a proximal housing component (101) housing a dose setting and expelling mechanism comprising a piston rod for exerting a force on the piston of the cartridge (113) in a distal direction for expelling a dose. The distal housing component (110) and the proximal housing component (101) are displaceably arranged in axial direction relative to each other for reducing an axial distance between the piston rod (120) and the piston of the cartridge (113). One of the distal housing component (110) and the proximal housing component (101) comprises a threaded adjustment component (103) being held at an axial fixed location on said one of the distal housing component (110) and the proximal housing component (101) and defining a first thread (103b) being in threaded engagement with a second thread (110b) defined by the other of the distal housing component (110) and the proximal housing component (101). After displacement the threaded adjustment component (103) is rotatably fixated so that the adjustment component (103) cannot be rotated without the use of a tool.La présente invention concerne un dispositif de distribution de médicaments pour expulser une dose de médicament d'une cartouche maintenue et qui définit une extrémité de sortie de médicament distale et une extrémité proximale opposée. Le dispositif de distribution de médicaments comprend : un composant de boîtier distal (110) maintenant une cartouche (113) comprenant un médicament liquide et un piston monté coulissant dans celle-ci dans une direction axiale, et un composant de boîtier proximal (101) logeant un mécanisme de réglage et d'expulsion de dose compre
