YOST, MICHAEL J.,GORE, MICHAEL C.,TERRACIO, LOUIS,GOODWIN, RICHARD L.,GOLDSMITH, EDIE C.
申请号：
CA2528134
公开号：
CA2528134C
申请日:
2004.06.04
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A tubular tissue scaffold is described which comprises a tube having a wall,wherein the wall includes biopolymer fibrils that are aligned in a helicalpattern around the longitudinal axis of the tube where the pitch of thehelical pattern changes with the radial position in the tube wall. Thescaffold is capable of directing the morphological pattern of attached andgrowing cells to form a helical pattern around the tube walls. Additionally,an apparatus for producing such a tubular tissue scaffold is disclosed, theapparatus comprising a biopolymer gel dispersion feed pump that is operablyconnected to a tube-forming device having an exit port, where the tube-formingdevice is capable of producing a tube from the gel dispersion while providingan angular shear force across the wall of the tube, and a liquid bath locatedto receive the tubular tissue scaffold from the tube-forming device. A methodfor producing the tubular tissue scaffolds is also disclosed. Also, artificialtissue comprising living cells attached to a tubular tissue scaffold asdescribed herein is disclosed. Methods for using the artificial tissue arealso disclosed.
