PROCESS FOR OBTAINING PURE MONOSIALOGANGLIOSIDE GM1 FOR MEDICAL USE

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专利权人:

LABORATOIRE MEDIDOM S.A.

发明人:

STEFANO CARLINO,RENÉ-PIERRE BUNTER

申请号：

MYPI 20081891

公开号：

MY157713A

申请日:

2008.06.02

申请国别(地区):

MY

年份:

2016

代理人:

摘要：

A PROCESS FOR PREPARING PURE MONOSIALOGANGLIOSIDE GM1 IN THE FORM OF ITS SODIUM SALT. THERE IS PROVIDED A PROCESS FOR THE ISOLATION AND PURIFICATION OF MONOSIALOGANGLIOSIDE GM1 COMPRISING (A) SEPARATION OF GM1 FROM A LIPIDIC MIXTURE CONTAINING THE MONOSIALOGANGLIOSIDE GM1 AS THE MAIN GANGLIOSIDE COMPONENT BY ION EXCHANGE COLUMN-CHROMATOGRAPHY USING AN ELUENT COMPRISING POTASSIUM OR CAESIUM IONS, (B) RECOVERY OF THE SOLUTE FROM THE ELUTED SOLUTION , (C) DIAFILTRATION OF AN AQUEOUS SOLUTION OF THE RECOVERED SOLUTE, AND (D) SECOND DIAFILTRATION AFTER THE ADDITION OF 1 M NACL, AND RECOVERING GM1. THE PURITY LEVEL OF GM1 OBTAINED IS HIGHER THAN 99.0%.

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中国工程科技知识中心

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http://www.ckcest.cn/home/