UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS;DARTMOUTH COLLEGE
发明人:
Alexandra HOWELL,Susan ESZTERHAS,Bryan Weston LUIKART
申请号：
US16300488
公开号：
US20190225956A1
申请日:
2017.05.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Compositions, methods and systems that inactivate proviral HIV-1 by genome editing to excise viral sequences, thereby inactivating production of nascent virus. In some embodiments, proviral DNA is excised by targeting the LTR region of integrated viral DNA using a CRISPR/Cas9 lentiviral construct. Use of the lentiviral construct advantageously permits transduction of both dividing and non-dividing target cells.
