Yuichi Hori,Kazunori Kataoka,Toshiro Fujita,Hideki Shimizu,Shinya Kaname,Satoru Matsumoto,Nobuhiro Nishiyama,Kanjiro Miyata,Makoto Oba
申请号：
US13259961
公开号：
US08668933B2
申请日:
2010.03.31
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided are a delivery system that is useful in delivering a double-stranded ribonucleic acid that functions in gene silencing in glomeruli, particularly in mesangial cells and the like, to the tissue or cells, and the like. A polyion complex in the form of a non-polymeric micelle consisting of a double-stranded ribonucleic acid and a block copolymer represented by the formula (I) or (II) below, which are electrostatically bound together, wherein the polyion complex has an average particle diameter of less than 100 nm as measured by a dynamic light scattering measuring method:wherein each symbol is as defined in the specification.
