Purine Derivatives, Pharmaceutical compositions containing same and Use thereof in the preparation of medicaments for treating Diseases Modulated by inhibition of Class I PI3K mTOR and / or
Their use, particularly for medical use in the treatment of Cancer and neurodegenerative disorders, and medicinal products containing them.Claim 1: a compound of the formula (1) or a pharmaceutically acceptable Salt thereof, wherein X represents N or CH； r1 represents the compound of formula (2) where R18 and R22 are independently Hydrogen, halogen, Hydroxy alkyl hydroxyl or c1-3； R19 R21 and repres Are independently Hydrogen, amino, hydroxyl, carboxyl, c1-3 alkoxyl alkyl, amino - C1 - 3C1-3 alkyl - C (= o) - NH -, c1-3 alkyl - (m s = o) NH - or Hydroxy alkyl c1-3； M is 0, 1 or 2； R20 represents Hydrogen, halogen or c1-3 alkoxyl； r1 is selected from the group of Formulae (3), which represents Hydrogen or Methyl R23, R24 represents Hydrogen, oxo or c1-3 alkyl； R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15R16 and R17 independently represent Hydrogen or Methyl； and R2 and R8 together form a Bridge or Ethylene； R2 and R6 together form a methylene Bridge or R12, R14 and together form a Bridge of ethylene and represents or, where chr25 or cr26r27 R25 is hydroxyl or alkoxyl C1 - 3 -R26, R27 and independently represent Hydrogen or Halogen； under the condition that the compound of the formula (1) is distinct from 2,6 di (IL - 8 - 4 - phenyl - 9h purine.Su uso médico, en particular su uso en el tratamiento del cáncer y trastornos neurodegenerativos, y medicamentos que los contienen.Reivindicación 1: Un compuesto de la fórmula (1), o una sal farmacéuticamente aceptable del mismo, en donde X representa N ó CH； R1 representa el compuesto de fórmula (2) en donde R18 y R22 representan independientemente hidrógeno, halógeno, hidroxilo o hidroxi-alquilo C1-3； R19 y R21 representan independientemente hidrógeno, amino, hidroxilo, carboxilo, alcoxilo C1-3, amino-alquilo C1-3, alquilo C1-3-C(=O)-NH-, alquilo C1-3-S(=O)m-NH o hidroxi-alquilo C1-3； m representa 0, 1 ó 2； R20 representa hidrógeno, halógeno o alcoxilo C1-3； o R1 se selecciona del grupo de fórmulas (3), en don
