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תולדות 6–ציקלואלקיל–5,1–דיהידרו–פיראזולו [4,3–d] פירימידינ–4–און והשימוש בהן כמעכבי a9pde
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
申请号:
IL22334712
公开号:
IL223347A
申请日:
2012.11.29
申请国别(地区):
IL
年份:
2017
代理人:
摘要:
Novel 6-Cycloalkyl-pyrazolopyrimidinones according to formula (I) with PDE9 inhibiting properties, wherein R 1 is a 5 or 6 membered aromatic heteroaryl-group, R 2 is an optional substituent, D is optionally substituted cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl or 2-, 3- or 4-pyridyl, m= 1 or 2 and n is 0, 1 or 2. The new compounds can be used as medicaments, in particular for the treatment of conditions concerning deficits in perception, concentration, learning or memory. Such conditions may be associated with Alzheimer's disease, schizophrenia and other diseases. The new compounds can be used in the treatment of cognitive impairment associated with such diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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