LHOTE GASTON Jennifer,GRASMAN NICHOLAS S,THEUERKAUF JORG,DE VRIES SJOERD A
申请号：
IN6673/CHENP/2013
公开号：
IN2013CN06673A
申请日:
2013.08.20
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
Polysaccharide derivatives having a median Equivalent Projected Circle Diameter (EQPC) of less than 140 micrometers and a particle size and shape distribution meeting condition A or B or both are useful for preparing dosage forms particularly for preparing compressed sustained release dosage forms: A. non compacted polysaccharide derivative particles have a flowability of at least 45 g/sec through a vertically inverted cone having a vertex angle of about 40 and an outlet diameter of about 50 mm or B. i) no more than 40 volume percent of the polysaccharide derivative particles are fine particles having a particle length LEFI of less than 40 micrometers and ii) no more than 40 volume percent of the polysaccharide derivative particles are fibrous particles and the sum of the fine particles and the fibrous particles does not exceed 50 volume percent.
