The disclosure provides methods of administering a composition comprising human bone marrow CD34+ (hBM34+) cells to a mammal in need thereof, whereby vascular damage in the blood-central nervous system barrier (B-CNS-B), such as in the blood-spinal cord barrier, of the mammal is repaired. The disclosure also provides a method of treating amyotrophic lateral sclerosis (ALS) in a mammal by administering a composition comprising human bone marrow CD34+ cells (hBM34+).
