Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis

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专利权人:

Memorial Sloan Kettering Cancer Center;Cornell University

发明人:

Bradbury, Michelle S.,Wiesner, Ulrich,Overholtzer, Michael,Scher, Howard,Ma, Kai

申请号：

AU2016271040

公开号：

AU2016271040A1

申请日:

2016.05.26

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution.

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中国工程科技知识中心

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http://www.ckcest.cn/home/