Charles William Blackledge, Jr.;Yanhong Feng;Jesus Raul Medina;Seth W. Grant;Gerald Patrick Brady, Jr.;Jeffrey Michael Axten;Stuart P. Romeril;William H. Miller
发明人:
Jeffrey Michael Axten,Charles William Blackledge, Jr.,Gerald Patrick Brady, Jr.,Yanhong Feng,Seth W. Grant,Jesus Raul Medina,William H. Miller,Stuart P. Romeril
申请号：
US13130368
公开号：
US08697685B2
申请日:
2009.11.18
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention is directed to 6-(4-pyrimidinyl)-1H-indazole derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R1-R4 are defined herein. The compounds of the invention axe inhibitors of PDK1 and can be useful in the treatment of immune and metabolic diseases and disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
