Marc Karel Jozef François,Willy Maria Albert Carlo Dries,Esther Dina Guido Basstanie
申请号：
US13538469
公开号：
US09320707B2
申请日:
2012.06.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention is concerned with a pharmaceutical composition suitable as a depot formulation for administration via intramuscular or subcutaneous injection, comprising:(1) as an active ingredient a therapeutically effective amount of a 9-hydroxyrisperidone fatty acid ester or a salt, or a stereoisomer or a stereoisomeric mixture thereof in submicron form and(2) a pharmaceutically acceptable carrier wherein the pharmaceutically acceptable carrier is water and the active ingredient is suspended therein:and with a process of preparing such a composition.The invention further concerns such a pharmaceutical composition for use as a medicament in the treatment of psychosis, schizophrenia, schizoaffective disorders, non-schizophrenic psychoses, behavioral disturbances associated with neurodegenerative disorders, e.g. in dementia, behavioral disturbances in mental retardation and autism, Tourettes syndrome, bipolar mania, depression, anxiety.
