Pfeifer, Andrea,Pihlgren Bosch, Maria,Muhs, Andreas,Watts, Ryan
申请号：
ES11192705
公开号：
ES2661562T3
申请日:
2007.07.13
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A humanized antibody or a fragment thereof, wherein said antibody or fragment thereof comprises: (A) (i) a Heavy Chain Variable Region (HCVR) having an amino acid sequence that is 96%, 97% , 5 98%, 99%, or 100% identical to the amino acid sequence of SEQ ID NO: 15, wherein the HCVR comprises a region determining the complementarity 1 (CDR1) of the heavy chain as provided in SEQ ID No. 1, a CDR2 of the heavy chain as provided in SEQ ID No. 2 and a CDR3 of the heavy chain as provided in SEQ ID No. 3, and (ii) a variable region of the light chain (LCVR) comprising a light chain CDR1 as provided in SEQ ID No. 4, a light chain CDR2 as provided in SEQ ID No. 5, RVSNRFS or KVSSRFS and a light chain CDR3 such as provided in SEQ ID NO: 6, or (B) (i) an HCVR comprising a heavy chain CDR1 as provided in SEQ ID NO: 1, a heavy chain CDR2 as provided in SEQ ID NO: 2 and a heavy chain CDR3 as provided in SEQ ID NO: 3, and (ii) an LCVR having an amino acid sequence that is 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence of SEQ ID NO: 12, wherein the LCVR comprises a light chain CDR1 as provided in SEQ ID NO: 4, a light chain CDR2 as provided in SEQ ID NO: 5, RVSNRFS or KVSSRFS and a light chain CDR3 as provided in SEQ ID NO: 6, wherein said antibody or fragment thereof is binds specifically to β-amyloid protein.Un anticuerpo humanizado o un fragmento del mismo, en el que dicho anticuerpo o fragmento del mismo comprende: (A) (i) una Región Variable de la Cadena Pesada (HCVR) que tiene una secuencia de aminoácidos que es un 96%, 97%, 5 98%, 99%, o 100% idéntica a la secuencia de aminoácidos de SEQ ID Nº: 15, en la que la HCVR comprende una región determinante de la complementariedad 1 (CDR1) de la cadena pesada tal como se proporciona en SEQ ID Nº: 1, una CDR2 de la cadena pesada tal como se proporciona en SEQ ID Nº: 2 y una CDR3 de la cadena pesada tal como se proporciona en SEQ ID Nº: 3, y (ii) una región variable de la cadena ligera (LCVR) que comprende una CDR1 d
