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Substituted [1,2,4] triazolo [1,5-a] pyrimidin-7-yl compounds as pde2 inhibitors
专利权人:
DART NEUROSCIENCE (CAYMAN) LTD
发明人:
Breitenbucher James,Freestone Graeme,Gomez Laurent,Lemus Robert,Ly Kiev,Mccarrick Margaret,Vernier William,Vickers Troy
申请号:
NZ72516115
公开号:
NZ725161A
申请日:
2015.04.22
申请国别(地区):
NZ
年份:
2017
代理人:
摘要:
The invention provides a chemical entity of Formula (I) wherein R1, R2, X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods as disclosed herein, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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