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COMPOSITIONS, SYNTHESIS, AND METHODS OF USING INDANONE BASED CHOLINESTERASE INHIBITORS
专利权人:
REVIVA PHARMACEUTICALS; INC.
发明人:
BHAT, LAXMINARAYAN,MOHAPATRA, PRABHU PRASAD
申请号:
NZ57818707
公开号:
NZ578187A
申请日:
2007.12.11
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is an indanone derivative of formula (II), (III), (IV) or (V) where an amide, ester, carbonate, phosphate, sulphate or carbamate either attached directly to the indanone or piperidine ring or is linked with a space. The other derivatives are as disclosed in the description. Also disclosed is a pharmaceutical composition comprising a compound of formula (II), (III), (IV) or (V) and the use of a compound of formula (II), (III), (IV) or (V) in the manufacture of a medicament for treating Alzheimers disease, myasthenia gravis, Huntingtons disease or glaucoma. Examples of compounds include: Ethyl 3-(( 4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)methyl)benzoate Ethyl 4-(4-(( 4-((5,6-dimethoxy-l-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)methyl)benzamido)butanoate and Isopropyl 4-((4-((5, 6-dimethoxy-l-oxo-2,3 -dihydro-1 H -inden-2-yl)methyl)piperidin-1-yl)methyl)benzoate.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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